To say that Mona Kawai is cute would be an understatement; she is breathtaking in every single way, and she knows it. At school, she is fawned over by boys and girls alike, and she graciously welcomes it all as a natural reaction to her irresistible charm. That is, until she comes across Medaka Kuroiwa, the boy who is seemingly immune to her overwhelming charisma. She goes out of her way to talk to him and even dials her cuteness up a notch, but no matter what she tries, Mona cannot wipe the scowl off Kuroiwa's face. Backed into a corner, Mona is forced to use the most devastating weapon in her arsenal: her physical allure. Such drastic measures would leave other boys foaming at their mouths, but Kuroiwa remains unfazed by her attempts. Little does Mona know that the only reason Kuroiwa just barely abstains from succumbing to her charms is because he is training to be a monk and thus trying his best not to be held down by worldly pleasures. As Mona goes all out to entice Kuroiwa, she fails to realize that his unintentional chivalry might just make her fall for him instead.

If there's one word to describe Reiji Ozora, it would be "quitter." He can never find the motivation to finish anything, and loses interest at the drop of a hat. This all changes when his best friend Maiko introduces him to the new game "Dragon Drive." In this virtual reality game, each player is assigned a dragon tailored to match their personality and strength. Reiji hopes for a big, strong, scary beast, but instead, he is stuck with Chibi, a cute, friendly-looking dragon smaller than he is. How disappointing—except it turns out that Chibi is the rarest dragon of them all! Reiji finally discovers something he can remain interested in, and works hard to train both himself and his newfound friend. Soon this training will be put to use to save the world, for there are people who have dark aspirations for Dragon Drive!

High school science-whiz Makoto Mizuhara is working on his newest project in preparation for the school festival, alongside his best friend Nanami Jinnai. Nanami's brother and Makoto's lifelong rival, the unscrupulous student council president Katsuhiko Jinnai, is under scrutiny for mishandling the school festival planning and is convinced that Makoto is plotting to steal his position. One night, as Makoto and Nanami are taking a break with their teacher Masamichi Fujisawa, Jinnai sneaks into the science lab and sabotages Makoto's device, which suddenly opens a portal that flings all four of them into another world! Upon arrival, Makoto is immediately attacked by a horde of giant bug monsters. While running from them, he comes across Fujisawa and a girl named Rune Venus. After Fujisawa fights off the monsters, a group of dignitaries arrives, looking for Rune, their princess. They inform Makoto and Fujisawa that they are in a world called El-Hazard and take them back to the palace of Roshtaria, their kingdom. Though her advisors are suspicious of the newcomers, Rune decrees that they are to be treated as guests and quickly befriends Makoto. Unaware that Nanami and Jinnai are in this world as well, Makoto gets to work trying to figure out a way back to Earth.

Following a bad experience teaching at a public high school that resulted in a break from working, Haruaki Abe eagerly takes up a new job at Hyakki Academy. Despite his cowardice, the novice teacher is motivated to do better this time around. However, his mind quickly changes when he finds out that everyone at the school is actually a supernatural being known as a youkai, leaving him glaringly out of place as the only human around. Facing his class as its new homeroom teacher, Abe immediately becomes a target for the students' antics due to his quick-to-scare nature. Though as the man starts to learn more about the creatures, as well as himself, getting along with the unruly group might not be as hard as he originally thought as their school lives begin to get more vibrant.