Attacker You! is the story of ambitious and energetic 13-year-old junior high schoolgirl You Hazuki (variously known as "Mila," "Jeanne" or "Juana" in Western dubbed versions of the anime), who moves to Tokyo from Osaka to live with her father Toshihiko, a cameraman recently returned from Peru, and attend school. You's mother is not in the picture, having left when You was very young. Also living with You and her father is her younger brother Sunny, who is very attached to his older sister and tends to follow her everywhere she goes, including to school and to her volleyball matches. You is also curious about Kyushi Tajima, the pretty blonde woman whom she sees covering volleyball games on television, and about why her father becomes very angry whenever You mentions her. You is passionate about volleyball and dreams of one day being a part of Japan's national women's volleyball team in the 1988 Seoul Olympics. She joins her school's girls' volleyball team and quickly becomes one of the top players, although her coach (who is also her homeroom teacher) is brutal and literally slaps his players around when they don't live up to his expectations. You begins a tumultuous friendship with former school volleyball champ and former arch-rival Nami Hayase (French name: "Peggy"), which comes to a head when the two girls join opposing professional teams. She also develops a crush on So Takiki, the captain of the Hikawa boys' volleyball team (known as "Shiro," "Serge" or "Sergio" in various Western versions), and puts as much effort into trying to win his heart as she does into her game.

In the year 2015, more than a decade has passed since the catastrophic event known as Second Impact befell mankind. During this time of recovery, a select few learned of beings known as the Angels—colossal malevolent entities with the intention of triggering the Third Impact and wiping out the rest of humanity.

Called into the city of Tokyo-3 by his father Gendou Ikari, teenager Shinji is thrust headlong into humanity's struggle. Separated from Gendou since the death of his mother, Shinji presumes that his father wishes to repair their shattered familial bonds; instead, he discovers that he was brought to pilot a giant machine capable of fighting the Angels, Evangelion Unit-01. Forced to battle against wave after wave of mankind's greatest threat, the young boy finds himself caught in the middle of a plan that could affect the future of humanity forever.

Nan-young is a scientist whose astronaut mom failed to return to Earth when things went awry during her Mars probe. Nan-young has always dreamed of exploring space too and longs to go to Mars in hopes of finding a trace of her mom. Her dream comes true when she is selected as one of the astronauts for a Mars probe project. Before she blasts off though, she meets Jay, a musician who also fixes retro sound instruments. It's all thanks to an old turntable that Nan-young inherited from her mom.

Sequel to .